Mycobacterium Tuberculosis Rifampicin Resistance

Rifampicin yakhala ikugwiritsidwa ntchito kwambiri pochiza odwala chifuwa chachikulu cha m'mapapo kuyambira kumapeto kwa zaka za m'ma 1970, ndipo imakhala ndi zotsatirapo zazikulu.Chakhala chisankho choyamba kufupikitsa chemotherapy ya odwala chifuwa chachikulu cha m'mapapo.Kukana kwa Rifampicin kumachitika makamaka chifukwa cha kusintha kwa jini ya rpoB.Ngakhale kuti mankhwala atsopano odana ndi chifuwa chachikulu akutuluka nthawi zonse, ndipo chithandizo chachipatala cha odwala chifuwa chachikulu cha m'mapapo chapitirizabe kusintha, padakali kusowa kwa mankhwala oletsa chifuwa chachikulu cha TB, ndipo chodabwitsa cha kugwiritsa ntchito mankhwala osokoneza bongo m'chipatala ndi chochepa kwambiri.Mwachionekere, Mycobacterium TB odwala matenda a m`mapapo mwanga TB sangakhoze kuphedwa kwathunthu mu nthawi yake, amene potsirizira pake kumabweretsa madigiri osiyana mankhwala kukana mu thupi la wodwalayo, kutalikitsa njira ya matenda, ndi kumawonjezera ngozi ya imfa ya wodwalayo.Chida ichi ndi choyenera kuzindikiritsa matenda a Mycobacterium tuberculosis komanso kuzindikira jini ya rifampicin, zomwe zimathandiza kumvetsetsa kukana kwa mankhwala kwa mycobacterium TB yemwe ali ndi matenda a chifuwa chachikulu ndi odwala, komanso kupereka njira zothandizira zothandizira chithandizo chamankhwala.