Munthu ROS1 Fusion Gene Mutation

ROS1 ndi transmembrane tyrosine kinase ya banja la insulin receptor.ROS1 fusion jini yatsimikiziridwa ngati jini ina yofunika yoyendetsa khansa ya m'mapapo yopanda maselo yaying'ono.Monga nthumwi ya mtundu watsopano wapadera wa ma molekyulu, zochitika za ROS1 fusion jini mu NSCLC Pafupifupi 1% mpaka 2% ROS1 makamaka imakumana ndi kusintha kwa majini mu ma exons 32, 34, 35 ndi 36. Ikaphatikizidwa ndi majini monga CD74, EZR, SLC34A2, ndi SDC4, ipitiliza kuyambitsa dera la ROS1 tyrosine kinase.ROS1 kinase yolumikizidwa mosadziwika bwino imatha kuyambitsa njira zolozera kumunsi monga RAS/MAPK/ERK, PI3K/Akt/mTOR, ndi JAK3/STAT3, potero kutenga nawo gawo pakuchulukira, kusiyanitsa ndi kusakhazikika kwa ma cell chotupa, ndikuyambitsa khansa.Pakati pa masinthidwe osakanikirana a ROS1, CD74-ROS1 imakhala pafupifupi 42%, EZR imakhala pafupifupi 15%, SLC34A2 imakhala pafupifupi 12%, ndipo SDC4 imakhala pafupifupi 7%.Kafukufuku wasonyeza kuti ATP-binding site of catalytic domain of ROS1 kinase ndi ATP-binding site of ALK kinase ali ndi homology mpaka 77%, kotero ALK tyrosine kinase yaing'ono molecule inhibitor crizotinib ndi zina zotero zimakhala zoonekeratu machiritso zotsatira. pochiza NSCLC ndi masinthidwe ophatikizika a ROS1.Choncho, kuzindikira kwa kusintha kwa ROS1 fusion ndiye maziko ndi maziko otsogolera kugwiritsa ntchito mankhwala a crizotinib.