Anthu CYP2C9 ndi VKORC1 Gene Polymorphism

Warfarin ndi anticoagulant yapakamwa yomwe imagwiritsidwa ntchito kwambiri masiku ano, yomwe cholinga chake ndi kupewa komanso kuchiza matenda a thromboembolic.Komabe, warfarin ili ndi zenera lochepa la chithandizo ndipo imasiyana kwambiri pakati pa mafuko ndi anthu osiyanasiyana.Ziwerengero zawonetsa kuti kusiyana kwa mlingo wokhazikika mwa anthu osiyanasiyana kumatha kupitilira nthawi za 20.The chokhwima anachita magazi kumachitika 15.2% ya odwala kutenga warfarin chaka chilichonse, amene 3.5% kukhala amapha magazi.Kafukufuku wa Pharmacogenomic awonetsa kuti genetic polymorphism ya chandamale enzyme VKORC1 ndi kagayidwe kachakudya ka CYP2C9 ya warfarin ndi chinthu chofunikira chomwe chimakhudza kusiyana kwa mlingo wa warfarin.Warfarin ndi inhibitor yeniyeni ya vitamini K epoxide reductase (VKORC1), motero imalepheretsa kaphatikizidwe ka clotting factor kuphatikiza vitamini K ndipo imapereka anticoagulation.Kafukufuku wambiri wasonyeza kuti jini ya polymorphism ya VKORC1 yolimbikitsa ndiye chinthu chofunikira kwambiri chomwe chimakhudza mpikisano ndi kusiyana kwa anthu pa mlingo wofunikira wa warfarin.Warfarin imapangidwa ndi CYP2C9, ndipo masinthidwe ake amachepetsa kwambiri kagayidwe ka warfarin.Anthu omwe amagwiritsa ntchito warfarin amakhala ndi chiopsezo chachikulu (kuwirikiza kawiri mpaka katatu) akutaya magazi atangoyamba kumene kugwiritsa ntchito.