Progesterone (P)

Progesterone ndi progestogen yofunikira, ya mahomoni a steroid, okhala ndi mamolekyulu olemera a 314.5.Amapangidwa makamaka ndi corpus luteum ya ovary ndi placenta pa nthawi ya mimba.Ndi kalambulabwalo wa testosterone, estrogen ndi adrenal cortex mahomoni.Mulingo wa progesterone wopangidwa panthawi ya follicular ya amuna ndi akazi omwe ali ndi vuto lochepa kwambiri, pambuyo potuluka m'magazi, amamangiriridwa ku albumin ndi mahomoni ogonana omwe amamanga mapuloteni ndikuzungulira mthupi.

Ntchito yaikulu ya progesterone ndi kupanga chiberekero kukonzekera kuikidwa kwa mazira okhwima ndi kusunga mimba.Panthawi ya follicular ya msambo, mlingo wa progesterone umakhala wotsika.Pambuyo pa ovulation, progesterone yopangidwa ndi corpus luteum imakula mofulumira, ndipo imafika pamlingo waukulu wa 10ng/mL-20ng/mL m’masiku 5-7 mutatha kutulutsa dzira.Ngati sanatengedwe, corpus luteum atrophies m'masiku anayi otsiriza a msambo ndipo ndende ya progesterone imachepa mpaka follicular gawo.Ngati pathupi, corpus luteum simazimiririka ndipo ikupitiriza kutulutsa progesterone, kuisunga pamiyeso yofanana ndi gawo lapakati la luteal ndikupitirira mpaka sabata lachisanu ndi chimodzi la mimba.Pakati pa mimba, placenta pang'onopang'ono imakhala gwero lalikulu la progesterone, ndipo kuchuluka kwake kumawonjezeka kuchoka pa 10ng/mL-50ng/mL m’miyezi itatu yoyambirira ya mimba kufika pa 50ng/mL-280ng/mL m’miyezi 7-9.Kafukufuku wazachipatala awonetsa kuti progesterone imathandizira kulimbikitsa kutulutsa kwa ovulation ndikusunga magwiridwe antchito a corpus luteum mwa amayi omwe sali oyembekezera.Ngati progesterone yopangidwa ndi corpus luteum ndi yosakwanira, ikhoza kusonyeza kuti ntchito ya corpus luteum ndi yosakwanira, ndipo ntchito yosakwanira ya corpus luteum ikugwirizana ndi kusabereka komanso kuperewera koyambirira.