Human Methylated NDRG4/SEPT9/SFRP2/BMP3/SDC2 Gene

Akuluakulu, oposa 10 8 matumbo epithelial maselo kugwa kuchokera m`matumbo khoma tsiku lililonse, ndipo excreted ndi ndowe kudzera lalikulu matumbo peristalsis.Chifukwa cha maselo chotupa ndi zambiri kugwa pa matumbo thirakiti kuchulukira kwachilendo, chopondapo cha odwala m`mimba chotupa ali ambiri matenda maselo ndi matenda a m`thupi zigawo zikuluzikulu, amene ndi zinthu maziko khola chopondapo kudziwika.Kafukufuku wapeza kuti kusinthidwa kwa methylation kwa olimbikitsa majini ndizochitika koyambirira kwa tumorigenesis, ndipo ma genetic omwe amatengedwa kuchokera ku chimbudzi cha odwala khansa ya colorectal amatha kuwonetsa kupezeka kwa khansa m'matumbo kale.

NDRG4, yomwe imadziwikanso kuti SMAP-8 ndi BDM1, ndi imodzi mwa mamembala anayi a NDRG gene family (NDRG1-4), yomwe yasonyezedwa kuti ikugwirizana ndi kuchuluka kwa maselo, kusiyanitsa, chitukuko ndi kupsinjika maganizo.Zimatsimikiziridwa kuti NDRG4 methylation ndiyomwe imapangitsa kuti anthu asazindikire khansa yapakhungu m'miyendo.

SEPT9 ndi membala wa banja la jini la Septin, lomwe lili ndi ma jini osachepera 13 omwe amaphatikiza madera otetezedwa a GTPase omwe amatha kumanga mapuloteni okhudzana ndi cytoskeleton, ndipo amalumikizidwa ndi kugawanika kwa ma cell ndi tumorigenesis.Kafukufuku wapeza kuti methylated Septin9 jini imachulukitsidwa mwachitsanzo cha odwala omwe ali ndi khansa ya colorectal.

Mapuloteni obisika okhudzana ndi frizzled (sFRPs) ndi mapuloteni osungunuka omwe ndi gulu la Wnt pathway antagonists chifukwa cha mapangidwe awo apamwamba a homology ku frizzled (Fz) receptor ya Wnt signing.Kusakhazikika kwa jini ya SFRP kumabweretsa kutsegulidwa kosalamulirika kwa chizindikiro cha Wnt chokhudzana ndi khansa ya colorectal.Pakadali pano, SFRP2 methylation mu chopondapo itha kugwiritsidwa ntchito ngati biomarker yosasokoneza pozindikira khansa yapakhungu.

BMP3 ndi membala wa TGF-B superfamily motero imagwira ntchito yofunika kwambiri pakukula kwa embryonic polimbikitsa ndi kupanga mapangidwe a mafupa oyambirira.BMP3 ndi hypermethylated mu khansa yapakhungu ndipo ingagwiritsidwe ntchito ngati cholembera chofunikira chotupa.

SDC2 ndi selo pamwamba pa heparan sulfate proteoglycan yomwe imakhudzidwa ndi kayendetsedwe kazinthu zambiri zakuthupi ndi zakuthambo.Zopangidwa mwakuthupi zimaphatikizapo kuchuluka kwa maselo, kusiyanitsa, kumamatira, gulu la cytoskeletal, kusamuka, kuchiritsa mabala, kulumikizana kwa ma cell, angiogenesis;Pathological njira monga kutupa ndi khansa.Mulingo wa methylation wa jini ya SDC2 mu minyewa ya khansa ya colorectal unali wokwera kwambiri kuposa wamtundu wamba.