Anthu EML4-ALK Fusion Gene Mutation

Chidachi chimagwiritsidwa ntchito pozindikira mitundu 12 yosinthira ya EML4-ALK gene fusion mu zitsanzo za odwala khansa ya m'mapapo ya anthu omwe si ang'onoang'ono a m'mapapo.Zotsatira zoyezetsa ndizongofotokozera zachipatala zokha ndipo siziyenera kugwiritsidwa ntchito ngati njira yokhayo yothandizira odwala payekhapayekha.Madokotala ayenera kupanga ziganizo zomveka bwino pa zotsatira za kuyezetsa kutengera zinthu monga momwe wodwalayo alili, zizindikiro za mankhwala, kuyankhidwa kwamankhwala, ndi zizindikiro zina zoyezetsa mu labotale.Khansara ya m'mapapo ndiyo chotupa choopsa kwambiri padziko lonse lapansi, ndipo 80% ~ 85% yamilanduyo ndi khansa ya m'mapapo yosakhala yaying'ono (NSCLC).Gene fusion ya echinoderm microtubule-associated protein-like 4 (EML4) ndi anaplastic lymphoma kinase (ALK) ndi chandamale chapagulu mu NSCLC, EML4 ndi ALK motsatana zili mwa anthu magulu a P21 ndi P23 pa chromosome 2 ndipo amasiyanitsidwa ndi pafupifupi 12.7 mamiliyoni oyambira awiri.Pafupifupi mitundu 20 yophatikizika yapezeka, mwa zomwe 12 zosinthika mu Table 1 ndizofala, pomwe mutant 1 (E13; A20) ndiye wofala kwambiri, wotsatiridwa ndi mutants 3a ndi 3b (E6; A20), wowerengera pafupifupi 33% ndi 29% ya odwala omwe ali ndi EML4-ALK fusion gene NSCLC, motero.Ma ALK inhibitors oimiridwa ndi Crizotinib ndi mankhwala ang'onoang'ono omwe amapangidwa kuti azitha kusintha ma gene fusion a ALK.Poletsa ntchito za dera la ALK tyrosine kinase, kutsekereza njira zake zolozera kunsi kwa mtsinje, potero zimalepheretsa kukula kwa maselo otupa, kuti akwaniritse chithandizo cha zotupa.Kafukufuku wachipatala wasonyeza kuti Crizotinib ili ndi mlingo wogwira mtima woposa 61% mwa odwala omwe ali ndi kusintha kwa kusintha kwa EML4-ALK, pamene ilibe mphamvu kwa odwala omwe ali ndi nyama zakutchire.Choncho, kuzindikira kwa kusintha kwa EML4-ALK fusion ndiyo maziko ndi maziko otsogolera kugwiritsa ntchito mankhwala a Crizotinib.