Munthu CYP2C19 Gene Polymorphism

CYP2C19 ndi imodzi mwama enzymes ofunikira omwe amasokoneza ma enzymes m'banja la CYP450.Magawo ambiri amkati komanso pafupifupi 2% yamankhwala amapangidwa ndi CYP2C19, monga kagayidwe ka antiplatelet aggregation inhibitors (monga clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, ndi zina zotero. mankhwala okhudzana.Kusintha kwa mfundo izi za *2 (rs4244285) ndi *3 (rs4986893) kumayambitsa kutayika kwa ntchito ya enzyme yosungidwa ndi jini ya CYP2C19 komanso kufooka kwa gawo la gawo lapansi la metabolic, ndikuwonjezera kuchuluka kwa magazi, kuti ayambitse zovuta zoyipa zokhudzana ndi ndende ya magazi.* 17 (rs12248560) imatha kukulitsa ntchito ya enzyme yosungidwa ndi jini ya CYP2C19, kupanga ma metabolites yogwira, komanso kukulitsa kuletsa kuphatikizika kwa mapulateleti ndikuwonjezera chiwopsezo chamagazi.Kwa anthu omwe ali ndi kagayidwe kake ka mankhwala osokoneza bongo, kumwa Mlingo wabwinobwino kwa nthawi yayitali kumayambitsa poizoni komanso zotsatirapo zoyipa: makamaka kuwonongeka kwa chiwindi, kuwonongeka kwa dongosolo la hematopoietic, kuwonongeka kwa dongosolo lamanjenje, ndi zina zambiri, zomwe zingayambitse imfa kwambiri.Malinga ndi kusiyanasiyana kwa kagayidwe kake ka mankhwala, nthawi zambiri amagawidwa m'magulu anayi, omwe ndi ultra-fast metabolism (UM, *17/*17,*1/*17), kagayidwe kachakudya (RM,*1/*1) ), metabolism yapakatikati (IM, *1/*2, *1/*3), slow metabolism (PM, *2/*2, *2/*3, *3/*3).