Munthu BCR-ABL Fusion Gene Mutation
Dzina la malonda
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Epidemiology
Chronic myelogenousleukemia (CML) ndi matenda oopsa a clonal a hematopoietic stem cell.Oposa 95% ya odwala CML amakhala ndi Philadelphia chromosome (Ph) m'maselo awo a magazi.Zomwe zimayambitsa matenda a CML ndi motere: Jini la BCR-ABL fusion limapangidwa ndi translocation pakati pa abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) pa mkono wautali wa chromosome 9 (9q34) ndi dera la breakpoint cluster ( BCR) jini pa mkono wautali wa chromosome 22 (22q11);puloteni yophatikizika yomwe ili ndi jini iyi imakhala ndi ntchito ya tyrosine kinase (TK), ndipo imayendetsa njira zake zolozera pansi (monga RAS, PI3K, ndi JAK/STAT) kulimbikitsa magawano a cell ndikuletsa apoptosis ya cell, kupangitsa kuti maselo azichulukana moyipa, motero kupezeka kwa CML.BCR-ABL ndi chimodzi mwa zizindikiro zofunika kwambiri za CML.Kusintha kwamphamvu kwa msinkhu wake wolembedwa ndi chizindikiro chodalirika cha chiweruzo cham'tsogolo cha khansa ya m'magazi ndipo ingagwiritsidwe ntchito kulosera kuyambiranso kwa khansa ya m'magazi pambuyo pa chithandizo.
Channel
| FAM | BCR-ABL fusion jini |
| VIC/HEX | Ulamuliro Wamkati |
Magawo aukadaulo
| Kusungirako | Zamadzimadzi: ≤-18 ℃ Mumdima |
| Alumali moyo | Madzi: 9 miyezi |
| Mtundu wa Chitsanzo | Zitsanzo za mafupa |
| LoD | 1000 Makopi / mL |
| Mwatsatanetsatane
| Palibe kuyanjananso ndi mitundu ina yophatikizika TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, ndi PML-RARa |
| Zida Zogwiritsira Ntchito | Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio® 5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
